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Sequence Detail
ID/Version
P28798 (UniProt | EBI) Last sequence update: 1994-10-01
Last annotation update: 2019-07-31
Sequence
description
from provider
RecName: Full=Progranulin {ECO:0000303|PubMed:12524533}; Short=PGRN {ECO:0000250|UniProtKB:P28799};AltName: Full=Acrogranin {ECO:0000303|PubMed:8482392};AltName: Full=Epithelin/granulin precursor {ECO:0000303|PubMed:8482392};AltName: Full=Glycopro
Provider SWISS-PROT
Sequence
Polypeptide 589 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Grn granulin 62 10 7 19
Sequence references in MGI J:4982 Baba T, et al., Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett. 1993 May 10;322(2):89-94
J:32404 Baba T, et al., Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells. Mol Reprod Dev. 1993 Mar;34(3):233-43
J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
J:167749 Hu F, et al., Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010 Nov 18;68(4):654-67
J:188324 Martens LH, et al., Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov;122(11):3955-9
J:227553 Zhou X, et al., Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. J Cell Biol. 2015 Sep 14;210(6):991-1002
J:242512 Tanaka Y, et al., Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes. Hum Mol Genet. 2017 Mar 01;26(5):969-988
J:243041 Beel S, et al., Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo. Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
J:250451 Zhou X, et al., Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations. Nat Commun. 2017 May 25;8:15277
J:269542 He Z, et al., Progranulin is a mediator of the wound response. Nat Med. 2003 Feb;9(2):225-9
J:269546 Jian J, et al., Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine. 2016 Nov;13:212-224
J:269551 Zhou X, et al., Lysosomal processing of progranulin. Mol Neurodegener. 2017 Aug 23;12(1):62
J:269644 Zhu J, et al., Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell. 2002 Dec 13;111(6):867-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory