Sequence Detail

ID/Version

P28798 (UniProt | EBI)

Last sequence update: 1994-10-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Progranulin {ECO:0000303|PubMed:12524533}; Short=PGRN {ECO:0000250|UniProtKB:P28799};AltName: Full=Acrogranin {ECO:0000303|PubMed:8482392};AltName: Full=Epithelin/granulin precursor {ECO:0000303|PubMed:8482392};AltName: Full=Glycopro

Provider

SWISS-PROT

Sequence

Polypeptide 589 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grn	granulin	92	106	4	27

Sequence references in MGI

J:4982 Baba T, et al., Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin). FEBS Lett. 1993 May 10;322(2):89-94
J:32404 Baba T, et al., Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells. Mol Reprod Dev. 1993 Mar;34(3):233-43
J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
J:167749 Hu F, et al., Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010 Nov 18;68(4):654-67
J:188324 Martens LH, et al., Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov;122(11):3955-9
J:227553 Zhou X, et al., Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. J Cell Biol. 2015 Sep 14;210(6):991-1002
J:242512 Tanaka Y, et al., Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes. Hum Mol Genet. 2017 Mar 01;26(5):969-988
J:243041 Beel S, et al., Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo. Hum Mol Genet. 2017 Aug 1;26(15):2850-2863
J:250046 Klein ZA, et al., Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron. 2017 Jul 19;95(2):281-296.e6
J:250451 Zhou X, et al., Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations. Nat Commun. 2017 May 25;8:15277
J:269542 He Z, et al., Progranulin is a mediator of the wound response. Nat Med. 2003 Feb;9(2):225-9
J:269546 Jian J, et al., Progranulin Recruits HSP70 to beta-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. EBioMedicine. 2016 Nov;13:212-224
J:269551 Zhou X, et al., Lysosomal processing of progranulin. Mol Neurodegener. 2017 Aug 23;12(1):62
J:269644 Zhu J, et al., Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell. 2002 Dec 13;111(6):867-78
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298997 Werner G, et al., Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. EMBO Rep. 2020 Oct 5;21(10):e50241
J:299153 Zhou X, et al., Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice. EMBO Rep. 2020 Oct 5;21(10):e50197
J:301380 Feng T, et al., Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020 Oct 5;21(10):e50219