Sequence Detail

ID/Version

P13297 Q9ERF6 Q91W75 (UniProt | EBI)

Last sequence update: 2013-11-13
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Homeobox protein MSX-1 {ECO:0000305};AltName: Full=Homeobox protein Hox-7;AltName: Full=Hox-7.1 {ECO:0000312|MGI:MGI:97168};AltName: Full=Msh homeobox 1-like protein;

Provider

SWISS-PROT

Sequence

Polypeptide 303 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Msx1	msh homeobox 1	122	297	3	20

Sequence references in MGI

J:9723 Hill RE, et al., A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1. Genes Dev. 1989 Jan;3(1):26-37
J:9747 Robert B, et al., Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J. 1989 Jan;8(1):91-100
J:11121 Holland PW, Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene. 1991 Feb 15;98(2):253-7
J:11525 Monaghan AP, et al., The Msh-like homeobox genes define domains in the developing vertebrate eye. Development. 1991 Aug;112(4):1053-61
J:17489 Satokata I, et al., Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development [see comments]. Nat Genet. 1994 Apr;6(4):348-56
J:36231 Chen Y, et al., Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996 Oct;122(10):3035-44
J:107295 Lee H, et al., PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein. Genes Dev. 2006 Apr 1;20(7):784-94
J:108971 Gupta V, et al., Modification of Msx1 by SUMO-1. Biochem Biophys Res Commun. 2006 Jun 23;345(1):74-7
J:114410 Jumlongras D, et al., A nonsense mutation in MSX1 causes Witkop syndrome. Am J Hum Genet. 2001 Jul;69(1):67-74
J:172494 Shetty S, et al., Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding protein, Sp1 and cAMP-response-element-binding protein-binding protein (CBP/p300). Biochem J. 1999 May 1;339(Pt 3):751-8
J:237943 Jia S, et al., Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol. 2016 Dec 01;420(1):110-119
J:321038 Xie H, et al., Msx1 homeodomain protein represses the alphaGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar;27(3):422-36
J:338223 Wang J, et al., The MSX1 homeoprotein recruits G9a methyltransferase to repressed target genes in myoblast cells. PLoS One. 2012;7(5):e37647
J:341423 Feng XY, et al., Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12
J:341424 Feng XY, et al., Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. Eur J Oral Sci. 2013 Oct;121(5):412-20