Sequence Detail

ID/Version

P11344 (UniProt | EBI)

Last sequence update: 2007-05-29
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Tyrosinase; EC=1.14.18.1;AltName: Full=Albino locus protein;AltName: Full=Monophenol monooxygenase;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 533 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tyr	tyrosinase	31	109	3	161

Sequence references in MGI

J:1962 Tsukamoto K, et al., A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase. EMBO J. 1992 Feb;11(2):519-26
J:9242 Kwon BS, et al., Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1301-9
J:9824 Kwon BS, et al., Molecular basis of mouse Himalayan mutation. Biochem Biophys Res Commun. 1989 May 30;161(1):252-60
J:10058 Kwon BS, et al., Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene. J Invest Dermatol. 1989 Nov;93(5):589-94
J:10488 Shibahara S, et al., A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85. Eur J Biochem. 1990 Apr 30;189(2):455-61
J:18122 Terao M, et al., Isolation and characterization of variant cDNAs encoding mouse tyrosinase. Biochem Biophys Res Commun. 1989 Mar 15;159(2):848-53
J:19279 Beermann F, et al., Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J. 1990 Sep;9(9):2819-26
J:32467 Muller G, et al., Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO J. 1988 Sep;7(9):2723-30
J:230050 Marubashi S, et al., RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J Biol Chem. 2016 Jan 15;291(3):1427-40
J:328663 Liu Y, et al., Ablation of Proton/Glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis. J Invest Dermatol. 2022 Apr 23;