Sequence Detail

ID/Version

P09922 (UniProt | EBI)

Last sequence update: 1989-07-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Interferon-induced GTP-binding protein Mx1;AltName: Full=Influenza resistance protein;AltName: Full=Myxoma resistance protein 1;AltName: Full=Myxovirus resistance protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 631 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Pseudogene	Mx1	MX dynamin-like GTPase 1	15	103	2	15

Sequence references in MGI

J:8132 Staeheli P, et al., Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell. 1986 Jan 17;44(1):147-58
J:9452 Staeheli P, et al., Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol Cell Biol. 1988 Oct;8(10):4518-23
J:9540 Hug H, et al., Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol. 1988 Aug;8(8):3065-79
J:145260 Tumpey TM, et al., The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. J Virol. 2007 Oct;81(19):10818-21
J:177738 Wisskirchen C, et al., Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49. J Biol Chem. 2011 Oct 7;286(40):34743-51
J:181094 Cilloniz C, et al., Molecular signatures associated with mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. J Virol. 2012 Mar;86(5):2437-46
J:187548 Frensing T, et al., Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells. Vaccine. 2011 Sep 22;29(41):7125-9