Sequence Detail

ID/Version

P06797 Q91UZ0 (UniProt | EBI)

Last sequence update: 1990-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Procathepsin L {ECO:0000305}; EC=3.4.22.15 {ECO:0000269|PubMed:8554545};AltName: Full=Cathepsin L1;AltName: Full=Major excreted protein; Short=MEP;AltName: Full=p39 cysteine proteinase;Contains: RecName: Full=Cathepsin L;Con

Provider

SWISS-PROT

Sequence

Polypeptide 334 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ctsl	cathepsin L	95	117	12	17

Sequence references in MGI

J:8349 Denhardt DT, et al., Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins. Cancer Res. 1986 Sep;46(9):4590-3
J:14793 Troen BR, et al., Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin. Biochem J. 1987 Sep 15;246(3):731-5
J:24185 Joseph LJ, et al., Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. J Clin Invest. 1988 May;81(5):1621-9
J:76333 Stypmann J, et al., Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6234-9
J:78460 Benavides F, et al., Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am J Pathol. 2002 Aug;161(2):693-703
J:82888 Nakagawa T, et al., Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science. 1998 Apr 17;280(5362):450-3
J:83877 Friedrichs B, et al., Thyroid functions of mouse cathepsins B, K, and L. J Clin Invest. 2003 Jun;111(11):1733-45
J:90511 Goulet B, et al., A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell. 2004 Apr 23;14(2):207-19
J:93563 Portnoy DA, et al., Cloning and characterization of a mouse cysteine proteinase. J Biol Chem. 1986 Nov 5;261(31):14697-703
J:112070 Honey K, et al., Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J Exp Med. 2002 May 20;195(10):1349-58
J:115604 Lennon-Dumenil AM, et al., The p41 isoform of invariant chain is a chaperone for cathepsin L. EMBO J. 2001 Aug 1;20(15):4055-64
J:125707 Yasothornsrikul S, et al., Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9590-5
J:271359 Fiebiger E, et al., Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002 Nov 4;196(9):1263-9
J:289459 Felbor U, et al., Secreted cathepsin L generates endostatin from collagen XVIII. EMBO J. 2000 Mar 15;19(6):1187-94
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89