Sequence Detail

ID/Version

P01731 (UniProt | EBI)

Last sequence update: 1986-07-21
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=T-cell surface glycoprotein CD8 alpha chain;AltName: Full=T-cell surface glycoprotein Lyt-2;AltName: CD_antigen=CD8a;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 247 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd8a	CD8 subunit alpha	31	100	3	21

Sequence references in MGI

J:7962 Nakauchi H, et al., Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5126-30
J:8124 Zamoyska R, et al., Two Lyt-2 polypeptides arise from a single gene by alternative splicing patterns of mRNA. Cell. 1985 Nov;43(1):153-63
J:8328 Liaw CW, et al., Structure, sequence, and polymorphism of the Lyt-2 T cell differentiation antigen gene. J Immunol. 1986 Aug 1;137(3):1037-43
J:9388 Youn HJ, et al., Nucleotide sequence analysis of the C.AKR Lyt-2a gene: structural polymorphism in alleles encoding the Lyt-2.1 T-cell surface alloantigen. Immunogenetics. 1988;28(5):345-52
J:37454 Nakauchi H, et al., Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2. Nucleic Acids Res. 1987 May 26;15(10):4337-47
J:50625 Kern PS, et al., Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity. 1998 Oct;9(4):519-30
J:68956 Fung-Leung WP, et al., CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell. 1991 May 3;65(3):443-9
J:89989 Madakamutil LT, et al., CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science. 2004 Apr 23;304(5670):590-3
J:168951 Shore DA, et al., The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I. J Mol Biol. 2008 Dec 31;384(5):1190-202