Sequence Detail

ID/Version

O88693 A2AN90 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Ceramide glucosyltransferase {ECO:0000305}; EC=2.4.1.80 {ECO:0000269|PubMed:10430909};AltName: Full=GLCT-1;AltName: Full=Glucosylceramide synthase; Short=GCS {ECO:0000303|PubMed:33361282};AltName: Full=Glycosylceramide syntha

Provider

SWISS-PROT

Sequence

Polypeptide 394 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ugcg	UDP-glucose ceramide glucosyltransferase	22	103	3	16

Sequence references in MGI

J:48204 Ichikawa S, et al., Molecular cloning and expression of mouse ceramide glucosyltransferase. Biochem Mol Biol Int. 1998 May;44(6):1193-202
J:51794 Ichikawa S, et al., Molecular cloning and characterization of the mouse ceramide glucosyltransferase gene. Biochem Biophys Res Commun. 1998 Dec 30;253(3):707-11
J:76736 Yamashita T, et al., A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9142-7
J:80111 Yamashita T, et al., Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis. Biochim Biophys Acta. 2002 Dec 19;1573(3):236-40
J:101155 Jennemann R, et al., Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12459-64
J:120270 Jennemann R, et al., Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis. J Biol Chem. 2007 Feb 2;282(5):3083-94
J:168047 Watanabe S, et al., Glycosphingolipid synthesis in cerebellar Purkinje neurons: roles in myelin formation and axonal homeostasis. Glia. 2010 Aug;58(10):1197-207
J:190398 Jennemann R, et al., Glycosphingolipids are essential for intestinal endocytic function. J Biol Chem. 2012 Sep 21;287(39):32598-616
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6
J:201085 Amen N, et al., Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing. Hum Mol Genet. 2013 Oct 15;22(20):4164-79
J:220421 Nordstrom V, et al., Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. PLoS Biol. 2013;11(3):e1001506
J:242701 von Gerichten J, et al., Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals. J Lipid Res. 2017 Jun;58(6):1247-1258
J:267314 Jennemann R, et al., Hepatic glycosphingolipid deficiency and liver function in mice. Hepatology. 2010 May;51(5):1799-809