Sequence Detail

ID/Version

O35280 Q9D0N2 Q8CI40 O54925 (UniProt | EBI)

Last sequence update: 2005-09-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase Chk1; EC=2.7.11.1 {ECO:0000269|PubMed:18243098};AltName: Full=CHK1 checkpoint homolog;AltName: Full=Checkpoint kinase-1;

Provider

SWISS-PROT

Sequence

Polypeptide 476 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Chek1	checkpoint kinase 1	73	114	3	27

Sequence references in MGI

J:42767 Sanchez Y, et al., Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 [see comments]. Science. 1997 Sep 5;277(5331):1497-501
J:46333 Flaggs G, et al., Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Curr Biol. 1997 Dec 1;7(12):977-86
J:62918 Takai H, et al., Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev. 2000 Jun 15;14(12):1439-47
J:62919 Liu Q, et al., Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000 Jun 15;14(12):1448-59
J:91266 Lam MH, et al., Chk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 2004 Jul;6(1):45-59
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122564 Yong W, et al., Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. J Biol Chem. 2007 May 18;282(20):14690-4
J:177150 Shimada M, et al., Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell. 2008 Jan 25;132(2):221-32
J:212062 Engelen E, et al., Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One. 2013;8(2):e56623
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89