Sequence Detail

ID/Version

Q8K1M6 Q8BNQ5 Q8BQ64 E9PUD2 Q8CGD0 Q8K1A1 (UniProt | EBI)

Last sequence update: 2024-03-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Dynamin-1-like protein {ECO:0000305}; EC=3.6.5.5 {ECO:0000269|PubMed:24508339, ECO:0000269|PubMed:29853636};AltName: Full=Dynamin family member proline-rich carboxyl-terminal domain less; Short=Dymple {ECO:0000303|PubMed:9422

Provider

SWISS-PROT

Sequence

Polypeptide 736 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dnm1l	dynamin 1-like	201	101	3	35

Sequence references in MGI

J:45166 Kamimoto T, et al., Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J Biol Chem. 1998 Jan 9;273(2):1044-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:153835 Wakabayashi J, et al., The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol. 2009 Sep 21;186(6):805-16
J:158142 Ishihara N, et al., Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 2009 Aug;11(8):958-66
J:185131 Kageyama Y, et al., Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. J Cell Biol. 2012 May 14;197(4):535-51
J:200469 Loson OC, et al., Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell. 2013 Mar;24(5):659-67
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:245375 Loson OC, et al., The mitochondrial fission receptor MiD51 requires ADP as a cofactor. Structure. 2014 Mar 04;22(3):367-77
J:260505 Schmitt K, et al., Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics. Cell Metab. 2018 Mar 6;27(3):657-666.e5
J:267099 Itoh K, et al., A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane. J Biol Chem. 2018 Jul 27;293(30):11809-11822
J:286525 Lee J, et al., A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 Sep 1;159(9):3321-3330
J:291773 Itoh K, et al., Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division. Elife. 2019 Oct 11;8:e44739
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302474 Han H, et al., PINK1 phosphorylates Drp1(S616) to regulate mitophagy-independent mitochondrial dynamics. EMBO Rep. 2020 Aug 5;21(8):e48686