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Sequence Detail
A0A0B4J1G0 Q3TC44 Q8R477 Q8R2R4 (UniProt | EBI) Last sequence update: 2015-03-04
Last annotation update: 2019-12-11
from provider
RecName: Full=Low affinity immunoglobulin gamma Fc region receptor IV {ECO:0000312|MGI:MGI:2179523};AltName: Full=CD16-2 {ECO:0000303|PubMed:12389094};AltName: Full=FcgammaRIV {ECO:0000303|PubMed:16039578};Flags: Precursor;
Polypeptide 249 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Fcgr4 Fc receptor, IgG, low affinity IV 14 3 7 11
Sequence references in MGI J:80483 Mechetina LV, et al., Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII. Immunogenetics. 2002 Oct;54(7):463-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100540 Nimmerjahn F, et al., FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity. 2005 Jul;23(1):41-51
J:123354 Hirano M, et al., IgEb immune complexes activate macrophages through FcgammaRIV binding. Nat Immunol. 2007 Jul;8(7):762-71
J:130906 Jakus Z, et al., Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes. J Immunol. 2008 Jan 1;180(1):618-29
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:144620 Mancardi DA, et al., FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest. 2008 Nov;118(11):3738-50
J:155482 Syed SN, et al., Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a. Eur J Immunol. 2009 Dec;39(12):3343-56
J:221858 Negishi-Koga T, et al., Immune complexes regulate bone metabolism through FcRgamma signalling. Nat Commun. 2015;6:6637

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory