J:144571, Perry JM; Harandi OF; Porayette P; Hegde S; Kannan AK; Paulson RF, Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling., Blood 2009 Jan 22;113(4):911-8
J:149820, Gao J; Graves S; Koch U; Liu S; Jankovic V; Buonamici S; El Andaloussi A; Nimer SD; Kee BL; Taichman R; Radtke F; Aifantis I, Hedgehog signaling is dispensable for adult hematopoietic stem cell function., Cell Stem Cell 2009 Jun 5;4(6):548-58
J:149819, Hofmann I; Stover EH; Cullen DE; Mao J; Morgan KJ; Lee BH; Kharas MG; Miller PG; Cornejo MG; Okabe R; Armstrong SA; Ghilardi N; Gould S; de Sauvage FJ; McMahon AP; Gilliland DG, Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis., Cell Stem Cell 2009 Jun 5;4(6):559-67
J:151981, Spence JR; Lange AW; Lin SC; Kaestner KH; Lowy AM; Kim I; Whitsett JA; Wells JM, Sox17 regulates organ lineage segregation of ventral foregut progenitor cells., Dev Cell 2009 Jul;17(1):62-74
J:147277, Lan Y; Jiang R, Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth., Development 2009 Apr;136(8):1387-96
J:154980, Seifert AW; Bouldin CM; Choi KS; Harfe BD; Cohn MJ, Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development., Development 2009 Dec;136(23):3949-57
J:148020, Hoffmann AD; Peterson MA; Friedland-Little JM; Anderson SA; Moskowitz IP, sonic hedgehog is required in pulmonary endoderm for atrial septation., Development 2009 May;136(10):1761-70
J:143478, Nolan-Stevaux O; Lau J; Truitt ML; Chu GC; Hebrok M; Fernandez-Zapico ME; Hanahan D, GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation., Genes Dev 2009 Jan 1;23(1):24-36
J:147584, Patterson VL; Damrau C; Paudyal A; Reeve B; Grimes DT; Stewart ME; Williams DJ; Siggers P; Greenfield A; Murdoch JN, Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway., Hum Mol Genet 2009 May 15;18(10):1719-39
J:147574, Norman RX; Ko HW; Huang V; Eun CM; Abler LL; Zhang Z; Sun X; Eggenschwiler JT, Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling., Hum Mol Genet 2009 May 15;18(10):1740-54
J:146198, Wall DS; Mears AJ; McNeill B; Mazerolle C; Thurig S; Wang Y; Kageyama R; Wallace VA, Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity., J Cell Biol 2009 Jan 12;184(1):101-12
J:155450, Milenkovic L; Scott MP; Rohatgi R, Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium., J Cell Biol 2009 Nov 2;187(3):365-74
J:147427, Vue TY; Bluske K; Alishahi A; Yang LL; Koyano-Nakagawa N; Novitch B; Nakagawa Y, Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice., J Neurosci 2009 Apr 8;29(14):4484-97
J:149518, Sakagami K; Gan L; Yang XJ, Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina., J Neurosci 2009 May 27;29(21):6932-44
J:147298, Zhao C; Chen A; Jamieson CH; Fereshteh M; Abrahamsson A; Blum J; Kwon HY; Kim J; Chute JP; Rizzieri D; Munchhof M; Vanarsdale T; Beachy PA; Reya T, Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia., Nature 2009 Jan 25;458(7239):776-779
J:154102, Cain JE; Islam E; Haxho F; Chen L; Bridgewater D; Nieuwenhuis E; Hui CC; Rosenblum ND, GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells., PLoS One 2009;4(10):e7313
J:153607, Hammond R; Blaess S; Abeliovich A, Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons., PLoS One 2009;4(9):e7007
J:151965, Liem KF Jr; He M; Ocbina PJ; Anderson KV, Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling., Proc Natl Acad Sci U S A 2009 Aug 11;106(32):13377-82
J:155826, King P; Paul A; Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages., Proc Natl Acad Sci U S A 2009 Dec 15;106(50):21185-90
J:153743, Purcell P; Joo BW; Hu JK; Tran PV; Calicchio ML; O'Connell DJ; Maas RL; Tabin CJ, Temporomandibular joint formation requires two distinct hedgehog-dependent steps., Proc Natl Acad Sci U S A 2009 Oct 27;106(43):18297-302
J:152259, Cheung HO; Zhang X; Ribeiro A; Mo R; Makino S; Puviindran V; Law KK; Briscoe J; Hui CC, The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling., Sci Signal 2009;2(76):ra29
J:132944, Kimura H; Ng JM; Curran T, Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure., Cancer Cell 2008 Mar;13(3):249-60
J:136079, Spassky N; Han YG; Aguilar A; Strehl L; Besse L; Laclef C; Ros MR; Garcia-Verdugo JM; Alvarez-Buylla A, Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool., Dev Biol 2008 May 1;317(1):246-59
J:135151, Sigulinsky CL; Green ES; Clark AM; Levine EM, Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina., Dev Biol 2008 May 15;317(2):560-75
J:138713, Cho A; Ko HW; Eggenschwiler JT, FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism., Dev Biol 2008 Sep 1;321(1):27-39
J:134674, Fogel JL; Chiang C; Huang X; Agarwala S, Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling., Dev Dyn 2008 May;237(5):1359-72
J:138572, Komada M; Saitsu H; Kinboshi M; Miura T; Shiota K; Ishibashi M, Hedgehog signaling is involved in development of the neocortex., Development 2008 Aug;135(16):2717-27
J:134987, Mak KK; Kronenberg HM; Chuang PT; Mackem S; Yang Y, Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy., Development 2008 Jun;135(11):1947-56
J:137136, Blaess S; Stephen D; Joyner AL, Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling., Development 2008 Jun;135(12):2093-103
J:132152, Chamberlain CE; Jeong J; Guo C; Allen BL; McMahon AP, Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning., Development 2008 Mar;135(6):1097-106
J:134643, Goddeeris MM; Rho S; Petiet A; Davenport CL; Johnson GA; Meyers EN; Klingensmith J, Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart., Development 2008 May;135(10):1887-95
J:138814, Lavine KJ; Long F; Choi K; Smith C; Ornitz DM, Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development., Development 2008 Sep;135(18):3161-71
J:141804, Fendrich V; Esni F; Garay MV; Feldmann G; Habbe N; Jensen JN; Dor Y; Stoffers D; Jensen J; Leach SD; Maitra A, Hedgehog signaling is required for effective regeneration of exocrine pancreas., Gastroenterology 2008 Aug;135(2):621-31
J:138862, Warr N; Powles-Glover N; Chappell A; Robson J; Norris D; Arkell RM, Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation., Hum Mol Genet 2008 Oct 1;17(19):2986-96
J:137685, Lavine KJ; Kovacs A; Ornitz DM, Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice., J Clin Invest 2008 Jul;118(7):2404-14
J:133725, Tran PV; Haycraft CJ; Besschetnova TY; Turbe-Doan A; Stottmann RW; Herron BJ; Chesebro AL; Qiu H; Scherz PJ; Shah JV; Yoder BK; Beier DR, THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia., Nat Genet 2008 Apr;40(4):403-10
J:135664, Han YG; Spassky N; Romaguera-Ros M; Garcia-Verdugo JM; Aguilar A; Schneider-Maunoury S; Alvarez-Buylla A, Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells., Nat Neurosci 2008 Mar;11(3):277-84
J:144348, Ohazama A; Johnson EB; Ota MS; Choi HJ; Porntaveetus T; Oommen S; Itoh N; Eto K; Gritli-Linde A; Herz J; Sharpe PT, Lrp4 modulates extracellular integration of cell signaling pathways in development., PLoS ONE 2008;3(12):e4092
J:133357, Abe Y; Oda-Sato E; Tobiume K; Kawauchi K; Taya Y; Okamoto K; Oren M; Tanaka N, Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2., Proc Natl Acad Sci U S A 2008 Mar 25;105(12):4838-43
J:139130, Breunig JJ; Sarkisian MR; Arellano JI; Morozov YM; Ayoub AE; Sojitra S; Wang B; Flavell RA; Rakic P; Town T, Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling., Proc Natl Acad Sci U S A 2008 Sep 2;105(35):13127-32
J:136735, Ha HY; Kim JB; Cho IH; Joo HJ; Kim KS; Lee KW; Sunwoo H; Im JY; Lee JK; Hong JH; Han PL, Morphogenetic lung defects of JSAP1-deficient embryos proceeds via the disruptions of the normal expressions of cytoskeletal and chaperone proteins., Proteomics 2008 Mar;8(5):1071-80
J:133905, Koyama E; Ochiai T; Rountree RB; Kingsley DM; Enomoto-Iwamoto M; Iwamoto M; Pacifici M, Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling., Ann N Y Acad Sci 2007 Nov;1116():100-12
J:123971, Hilton MJ; Tu X; Long F, Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage., Dev Biol 2007 Aug 1;308(1):93-105
J:117334, Gritli-Linde A; Hallberg K; Harfe BD; Reyahi A; Kannius-Janson M; Nilsson J; Cobourne MT; Sharpe PT; McMahon AP; Linde A, Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling., Dev Cell 2007 Jan;12(1):99-112
J:117221, Shibukawa Y; Young B; Wu C; Yamada S; Long F; Pacifici M; Koyama E, Temporomandibular joint formation and condyle growth require Indian hedgehog signaling., Dev Dyn 2007 Feb;236(2):426-34
J:128368, White AC; Lavine KJ; Ornitz DM, FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network., Development 2007 Oct;134(20):3743-52
J:128367, Astorga J; Carlsson P, Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4., Development 2007 Oct;134(20):3753-61
J:121553, Allen BL; Tenzen T; McMahon AP, The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development., Genes Dev 2007 May 15;21(10):1244-57
J:130973, Balordi F; Fishell G, Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal., J Neurosci 2007 Dec 26;27(52):14248-59
J:121967, Balordi F; Fishell G, Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons., J Neurosci 2007 May 30;27(22):5936-47
J:123161, Rohatgi R; Milenkovic L; Scott MP, Patched1 regulates hedgehog signaling at the primary cilium., Science 2007 Jul 20;317(5836):372-6
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J:104803, Eggenschwiler JT; Bulgakov OV; Qin J; Li T; Anderson KV, Mouse Rab23 regulates Hedgehog signaling from Smoothened to Gli proteins., Dev Biol 2006 Feb 1;290(1):1-12
J:110602, Lin L; Bu L; Cai CL; Zhang X; Evans S, Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis., Dev Biol 2006 Jul 15;295(2):756-63
J:119575, Long F; Joeng KS; Xuan S; Efstratiadis A; McMahon AP, Independent regulation of skeletal growth by Ihh and IGF signaling., Dev Biol 2006 Oct 1;298(1):327-33
J:105834, Varjosalo M; Li SP; Taipale J, Divergence of hedgehog signal transduction mechanism between drosophila and mammals., Dev Cell 2006 Feb;10(2):177-86
J:113421, Szczepny A; Hime GR; Loveland KL, Expression of hedgehog signalling components in adult mouse testis., Dev Dyn 2006 Nov;235(11):3063-70
J:114494, Rodda SJ; McMahon AP, Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors., Development 2006 Aug;133(16):3231-44
J:104380, Hu MC; Mo R; Bhella S; Wilson CW; Chuang PT; Hui CC; Rosenblum ND, GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis., Development 2006 Feb;133(3):569-78
J:108509, Blaess S; Corrales JD; Joyner AL, Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region., Development 2006 May;133(9):1799-809
J:108507, Corrales JD; Blaess S; Mahoney EM; Joyner AL, The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation., Development 2006 May;133(9):1811-21
J:104154, Rice R; Connor E; Rice DP, Expression patterns of Hedgehog signalling pathway members during mouse palate development., Gene Expr Patterns 2006 Jan;6(2):206-12
J:103820, Reiter JF; Skarnes WC, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition., Genes Dev 2006 Jan 1;20(1):22-7
J:113403, Kim JW; Lemke G, Hedgehog-regulated localization of Vax2 controls eye development., Genes Dev 2006 Oct 15;20(20):2833-47
J:115750, Dakubo GD; Mazerolle CJ; Wallace VA, Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice., J Neurooncol 2006 Sep;79(3):221-7
J:112555, El Andaloussi A; Graves S; Meng F; Mandal M; Mashayekhi M; Aifantis I, Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus., Nat Immunol 2006 Apr;7(4):418-26
J:106707, Lien WH; Klezovitch O; Fernandez TE; Delrow J; Vasioukhin V, alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway., Science 2006 Mar 17;311(5767):1609-12
J:103514, May SR; Ashique AM; Karlen M; Wang B; Shen Y; Zarbalis K; Reiter J; Ericson J; Peterson AS, Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli., Dev Biol 2005 Nov 15;287(2):378-89
J:98927, Lipinski RJ; Cook CH; Barnett DH; Gipp JJ; Peterson RE; Bushman W, Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development., Dev Dyn 2005 Jul;233(3):829-36
J:102950, Xu Q; Wonders CP; Anderson SA, Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon., Development 2005 Nov;132(22):4987-98
J:112545, Wang XP; Aberg T; James MJ; Levanon D; Groner Y; Thesleff I, Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth., J Dent Res 2005 Feb;84(2):138-43
J:96412, Sacedon R; Diez B; Nunez V; Hernandez-Lopez C; Gutierrez-Frias C; Cejalvo T; Outram SV; Crompton T; Zapata AG; Vicente A; Varas A, Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis., J Immunol 2005 Feb 1;174(3):1456-61
J:102118, Corbit KC; Aanstad P; Singla V; Norman AR; Stainier DY; Reiter JF, Vertebrate Smoothened functions at the primary cilium., Nature 2005 Oct 13;437(7061):1018-21
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J:100466, Huangfu D; Anderson KV, Cilia and Hedgehog responsiveness in the mouse., Proc Natl Acad Sci U S A 2005 Aug 9;102(32):11325-30
J:93296, Yu H; Wessels A; Chen J; Phelps AL; Oatis J; Tint GS; Patel SB, Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome., BMC Dev Biol 2004 Mar 2;4(1):1
J:89200, Jaskoll T; Leo T; Witcher D; Ormestad M; Astorga J; Bringas P Jr; Carlsson P; Melnick M, Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis., Dev Dyn 2004 Apr;229(4):722-32
J:88577, Mu X; Beremand PD; Zhao S; Pershad R; Sun H; Scarpa A; Liang S; Thomas TL; Klein WH, Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina., Development 2004 Mar;131(6):1197-210
J:88635, Long F; Chung UI; Ohba S; McMahon J; Kronenberg HM; McMahon AP, Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton., Development 2004 Mar;131(6):1309-18
J:93609, Fuccillo M; Rallu M; McMahon AP; Fishell G, Temporal requirement for hedgehog signaling in ventral telencephalic patterning., Development 2004 Oct;131(20):5031-40
J:92048, Vokes SA; Yatskievych TA; Heimark RL; McMahon J; McMahon AP; Antin PB; Krieg PA, Hedgehog signaling is essential for endothelial tube formation during vasculogenesis., Development 2004 Sep;131(17):4371-80
J:100340, Mori T; Yuxing Z; Takaki H; Takeuchi M; Iseki K; Hagino S; Kitanaka J; Takemura M; Misawa H; Ikawa M; Okabe M; Wanaka A, The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons., Eur J Neurosci 2004 Jun;19(12):3129-41
J:88344, Miao D; Liu H; Plut P; Niu M; Huo R; Goltzman D; Henderson JE, Impaired endochondral bone development and osteopenia in Gli2-deficient mice., Exp Cell Res 2004 Mar 10;294(1):210-22
J:89445, Jeong J; Mao J; Tenzen T; Kottmann AH; McMahon AP, Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia., Genes Dev 2004 Apr 15;18(8):937-51
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J:86613, Allen M; Grachtchouk M; Sheng H; Grachtchouk V; Wang A; Wei L; Liu J; Ramirez A; Metzger D; Chambon P; Jorcano J; Dlugosz AA, Hedgehog signaling regulates sebaceous gland development., Am J Pathol 2003 Dec;163(6):2173-8
J:82736, Charron F; Stein E; Jeong J; McMahon AP; Tessier-Lavigne M, The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance., Cell 2003 Apr 4;113(1):11-23
J:86588, Hayashi S; Tenzen T; McMahon AP, Maternal inheritance of Cre activity in a Sox2Cre deleter strain., Genesis 2003 Oct;37(2):51-3
J:86350, Schwab K; Patterson LT; Aronow BJ; Luckas R; Liang HC; Potter SS, A catalogue of gene expression in the developing kidney., Kidney Int 2003 Nov;64(5):1588-604
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J:68722, Dyer MA; Farrington SM; Mohn D; Munday JR; Baron MH, Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo., Development 2001 May;128(10):1717-30
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