References
Query Results -- Details
MGI Accession ID: MGI:3577153
J Number: J:98108
Other Accession IDs:
Title: Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.
Authors: Wang P; Yang G; Mosier DR; Chang P; Zaidi T; Gong YD; Zhao NM; Dominguez B; Lee KF; Gan WB; Zheng H
Journal: J Neurosci
Volume: 25
Issue: 5
Date: 2005 Feb 2
Year: 2005
Pages: 1219-25
Review Status: Peer Reviewed
Abstract:
Biochemical and genetic studies place the amyloid precursor protein (APP) at the center stage of Alzheimer's disease (AD) pathogenesis. Although mutations in the APP gene lead to dominant inheritance of familial AD, the normal function of APP remains elusive. Here, we report that the APP family of proteins plays an essential role in the development of neuromuscular synapses. Mice deficient in APP and its homolog APP-like protein 2 (APLP2) exhibit aberrant apposition of presynaptic marker proteins with postsynaptic acetylcholine receptors and excessive nerve terminal sprouting. The number of synaptic vesicles at presynaptic terminals is dramatically reduced. These structural abnormalities are accompanied by defective neurotransmitter release and a high incidence of synaptic failure. Our results identify APP/APLP2 as key regulators of structure and function of developing neuromuscular synapses.
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