References
Query Results -- Details
MGI Accession ID: MGI:3530194
J Number: J:96346
Other Accession IDs:
Title: Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.
Authors: Stokin GB; Lillo C; Falzone TL; Brusch RG; Rockenstein E; Mount SL; Raman R; Davies P; Masliah E; Williams DS; Goldstein LS
Journal: Science
Volume: 307
Issue: 5713
Date: 2005 Feb 25
Year: 2005
Pages: 1282-8
Review Status: Peer Reviewed
Abstract:
We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimer's disease in humans. Axonal defects consisted of swellings that accumulated abnormal amounts of microtubule-associated and molecular motor proteins, organelles, and vesicles. Impairing axonal transport by reducing the dosage of a kinesin molecular motor protein enhanced the frequency of axonal defects and increased amyloid-beta peptide levels and amyloid deposition. Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease.
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