References
Query Results -- Details
MGI Accession ID: MGI:3527931
J Number: J:95893
Other Accession IDs:
Title: Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.
Authors: Perreault N; Sackett SD; Katz JP; Furth EE; Kaestner KH
Journal: Genes Dev
Volume: 19
Issue: 3
Date: 2005 Feb 1
Year: 2005
Pages: 311-5
Review Status: Peer Reviewed
Abstract:
Constitutive activation of the Wnt/APC/beta-catenin pathway is a frequent initiating event in gastrointestinal carcinogenesis. Mutations in the Adenomatous Polyposis Coli (APC) gene up-regulate Wnt signaling by stabilizing beta-catenin and causing activation of targets important in proliferation control. Here we show that loss of the mesenchymal transcription factor Foxl1 leads to a marked increase in tumor multiplicity in the colon of Apc(Min) mice. Apc(Min/+);Foxl1-/- mice also develop gastric tumors not observed in Apc(Min) mice. These effects are caused by earlier tumor initiation due to accelerated loss of heterozygosity (LOH) at the Apc locus. Foxl1 is the first mesenchymal Modifier of Min and plays a key role in gastrointestinal tumorigenesis.
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