References
Query Results -- Details
MGI Accession ID: MGI:3521594
J Number: J:94836
Other Accession IDs:
Title: Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.
Authors: Lee MM; Yoon BJ; Osiewicz K; Preston M; Bundy B; van Heeckeren AM; Werb Z; Soloway PD
Journal: Infect Immun
Volume: 73
Issue: 1
Date: 2005 Jan
Year: 2005
Pages: 661-5
Review Status: Peer Reviewed
Abstract:
Tissue inhibitor of metalloproteinase 1 (TIMP-1)-deficient mice are resistant to Pseudomonas aeruginosa corneal infections. Corneas healed completely in TIMP-1-deficient mice, and infections were cleared faster in TIMP-1-deficient mice than in wild-type littermates. Genetic suppression studies using matrix metalloproteinase (MMP)-deficient mice showed that MMP-9, MMP-3, and MMP-7 but not MMP-2 or MMP-12 are needed for resistance. Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance.
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