References
Query Results -- Details
MGI Accession ID: MGI:3505676
J Number: J:93780
Other Accession IDs:
Title: Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors.
Authors: Nishikawa M; Chang B; Inoue M
Journal: Carcinogenesis
Volume: 25
Issue: 11
Date: 2004 Nov
Year: 2004
Pages: 2101-5
Review Status: Peer Reviewed
Abstract:
To elucidate the role of nitric oxide (NO) in tumor cell growth in vivo, dynamic aspects of the growth of Ehrlich ascites tumor cells (EATCs) were studied in wild-type (WT) mice and in an inducible strain of NO synthase (iNOS)-deficient (iNOS(-/-)) mice. Kinetic analysis showed that the rate of free tumor cell growth in the peritoneal cavity was significantly higher in the iNOS(-/-) mice than in the WT mice. In contrast, EATCs inoculated subcutaneously rapidly grew and formed a solid tumor in WT mice, but failed to grow in iNOS(-/-) mice. These results clearly indicate that NO generated by iNOS predominantly inhibits the growth of tumor cells in their free form, but enhances the growth of solid tumors.
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