References
Query Results -- Details
MGI Accession ID: MGI:3055679
J Number: J:93064
Other Accession IDs:
Title: Monoallelic expression of mouse Cd4 gene.
Authors: Capparelli R; Costabile A; Viscardi M; Iannelli D
Journal: Mamm Genome
Volume: 15
Issue: 8
Date: 2004 Aug
Year: 2004
Pages: 579-84
Review Status: Peer Reviewed
Abstract:
A 7-bp deletion in the Cd4 gene, present in the strain MOLF/Ei of Mus musculus molossinus and absent in laboratory mouse strains ( Mus musculus musculus), provided the means to distinguish the parental origin of the Cd4 alleles expressed in single cells of F1 (AKR x MOLF/Ei) and F1 (Balb/C x MOLF/Ei) hybrids. Single-cell RT-PCR showed that the individual CD4+ lymphocyte expresses either the maternal or the paternal Cd4 allele, never both. In situ hybridization proved that Cd4 alleles replicate asynchronously, as expected in the case of genes expressed monoallelically.
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