References
Query Results -- Details
MGI Accession ID: MGI:3052374
J Number: J:92307
Other Accession IDs:
Title: Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders.
Authors: Staelens J; Puimege L; Mahieu T; Pynaert G; Hochepied T; Vandenabeele A; Grooten J; Kontoyiannis D; Van Roy F; Kollias G; Libert C
Journal: Mamm Genome
Volume: 15
Issue: 7
Date: 2004 Jul
Year: 2004
Pages: 537-43
Review Status: Peer Reviewed
Abstract:
Most inflammatory disorders are becoming more prevalent, especially in Western countries. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) plays a prominent role in many of these inflammatory disorders. We have previously shown that SPRET/Ei mice exhibit an extreme and dominant resistance to high doses of TNF. In this report, we investigate the response of heterozygous (C57BL/6xSPRET/Ei)F1 mice in different models of inflammatory diseases. Compared with C57BL/6 mice, (B x S)F1 mice are protected against TNF-induced arthritis and are partially protected against allergic asthma in an ovalbumin-induced model. However, these mice display complete susceptibility to TNF-induced inflammatory bowel disease. These results indicate that the SPRET/Ei genome harbors potent dominant antiinflammatory genes that might be relevant for the treatment of certain chronic inflammatory diseases. It is very well possible that different genes are implicated in the different models.
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