References
Query Results -- Details
MGI Accession ID: MGI:3047470
J Number: J:91565
Other Accession IDs:
Title: Postnatal refinement of peripheral olfactory projections.
Authors: Zou DJ; Feinstein P; Rivers AL; Mathews GA; Kim A; Greer CA; Mombaerts P; Firestein S
Journal: Science
Volume: 304
Issue: 5679
Date: 2004 Jun 25
Year: 2004
Pages: 1976-9
Review Status: Peer Reviewed
Abstract:
Axonal projections from the olfactory epithelium to the olfactory bulb are organized into glomeruli according to the expressed odorant receptor. Using gene-targeted mice, we show that glomerular maturation proceeds along different time courses for two similar receptors and requires sensory input during distinct sensitive periods. During early development, some glomeruli are innervated by axons of neurons that do not express the same receptor. These heterogeneous glomeruli normally disappear with age, but they persist in adults deprived of sensory input by unilateral and permanent naris closure. Persistence may be due, in part, to prolonged survival of olfactory sensory neurons.
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