References
Query Results -- Details
MGI Accession ID: MGI:3044515
J Number: J:90730
Other Accession IDs:
Title: Osteosarcomas in transgenic mice expressing an alpha-amylase-SV40 T-antigen hybrid gene.
Authors: Knowles BB; McCarrick J; Fox N; Solter D; Damjanov I
Journal: Am J Pathol
Volume: 137
Issue: 2
Date: 1990 Aug
Year: 1990
Pages: 259-62
Review Status: Peer Reviewed
Abstract:
Mice of a transgenic mouse lineage 501, produced by zygotic injection of the parotid alpha-amylase promoter-SV40 T-antigen hybrid gene, developed osteosarcomas at about 15 months of age. The tumors predominantly involved the axial skeleton, were sometimes multiple, and metastasized to the liver. A cell line derived from a primary tumor produced osteosarcomas on transfer to nude mice. The 501 transgenic lineage thus provides a valuable new model for studying the histogenesis of osteosarcomas.
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