References
Query Results -- Details
MGI Accession ID: MGI:3044500
J Number: J:90716
Other Accession IDs:
Title: A contextual model for axonal sorting into glomeruli in the mouse olfactory system.
Authors: Feinstein P; Mombaerts P
Journal: Cell
Volume: 117
Issue: 6
Date: 2004 Jun 11
Year: 2004
Pages: 817-31
Review Status: Peer Reviewed
Abstract:
No models fully account for how odorant receptors (ORs) function in the guidance of axons of olfactory sensory neurons (OSNs) to glomeruli in the olfactory bulb. Here, we use gene targeting in mice to demonstrate that the OR amino acid sequence imparts OSN axons with an identity that allows them to coalesce into glomeruli. Replacements between the coding regions of the M71 and M72 OR genes reroute axons to their respective glomeruli. A series of M71-M72 hybrid ORs uncover a spectrum of glomerular phenotypes, leading to the concept that the identity of OSN axons is revealed depending on what other axons are present. Naturally occurring amino acid polymorphisms in other ORs also produce distinct axonal identities. These critical amino acid residues are distributed throughout the protein and reside predominantly within transmembrane domains. We propose a contextual model for axon guidance in which ORs mediate homotypic interactions between like axons.
Additional Information:
