References
Query Results -- Details
MGI Accession ID: MGI:3042527
J Number: J:90105
Other Accession IDs:
Title: Genetic dissection of complex traits with chromosome substitution strains of mice.
Authors: Singer JB; Hill AE; Burrage LC; Olszens KR; Song J; Justice M; O'Brien WE; Conti DV; Witte JS; Lander ES; Nadeau JH
Journal: Science
Volume: 304
Issue: 5669
Date: 2004 Apr 16
Year: 2004
Pages: 445-8
Review Status: Peer Reviewed
Abstract:
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. The CSS panel consists of 22 mouse strains, each of which carries a single chromosome substituted from a donor strain (A/J) onto a common host background (C57BL/6J). A survey of 53 traits revealed evidence for 150 QTLs affecting serum levels of sterols and amino acids, diet-induced obesity, and anxiety. These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains.
Additional Information:
