References
Query Results -- Details
MGI Accession ID: MGI:3029033
J Number: J:88031
Other Accession IDs:
Title: Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain.
Authors: Qiao X; Pennesi M; Seong E; Gao H; Burmeister M; Wu SM
Journal: Vision Res
Volume: 43
Issue: 8
Date: 2003 Apr
Year: 2003
Pages: 859-65
Review Status: Peer Reviewed
Abstract:
The mocha mouse is a spontaneous mutant carrying a defective adaptor-like protein complex AP-3delta subunit. We examined retinal function and histology of the mocha mutant. We found that not only mocha homozygotes but also other littermates in the inbred strain are blind due to severe defects in both rod and cone photoreceptors on electroretinogram recordings. The functional deficit was caused by rapid, early postnatal photoreceptor degeneration. Genotyping confirmed the presence of a viral insertion of rd1 gene in the mocha strain. We conclude that rd1 allele contamination is primarily responsible for photoreceptor degeneration, and caution against behavioral tests with visual cues in the present stocks.
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