References
Query Results -- Details
MGI Accession ID: MGI:3028822
J Number: J:88013
Other Accession IDs:
Title: Modifier genes in mice and humans.
Authors: Nadeau JH
Journal: Nat Rev Genet
Volume: 2
Issue: 3
Date: 2001 Mar
Year: 2001
Pages: 165-74
Review Status: Peer Reviewed
Abstract:
An emerging theme of studies with spontaneous, engineered and induced mutant mice is that phenotypes often depend on genetic background, implying that genetic modifiers have a role in guiding the functional consequences of genetic variation. Understanding the molecular and cellular basis by which modifier genes exert their influence will provide insights into developmental and physiological pathways that are critical to fundamental biological processes, as well as into novel targets for therapeutic interventions in human diseases.
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