References
Query Results -- Details
MGI Accession ID: MGI:2682128
J Number: J:86814
Other Accession IDs:
Title: Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.
Authors: Gu Y; Filippi MD; Cancelas JA; Siefring JE; Williams EP; Jasti AC; Harris CE; Lee AW; Prabhakar R; Atkinson SJ; Kwiatkowski DJ; Williams DA
Journal: Science
Volume: 302
Issue: 5644
Date: 2003 Oct 17
Year: 2003
Pages: 445-9
Review Status: Peer Reviewed
Abstract:
The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas Rac1-/- but not Rac2-/- HSC/Ps fail to engraft in the bone marrow of irradiated recipient mice. In contrast, Rac2, but not Rac1, regulates superoxide production and directed migration in neutrophils, and in each cell type, the two GTPases play distinct roles in actin organization, cell survival, and proliferation. Thus, Rac1 and Rac2 regulate unique aspects of hematopoietic development and function.
Additional Information:
