References
Query Results -- Details
MGI Accession ID: MGI:2677621
J Number: J:85972
Other Accession IDs:
Title: Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1.
Authors: Eason DD; LeBron C; Coppola D; Moscinski LC; Livingston S; Sutton ET; Blanck G
Journal: Oncogene
Volume: 22
Issue: 40
Date: 2003 Sep 18
Year: 2003
Pages: 6166-76
Review Status: Peer Reviewed
Abstract:
Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies.
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