References
Query Results -- Details
MGI Accession ID: MGI:2677084
J Number: J:85811
Other Accession IDs:
Title: Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity.
Authors: Hanada T; Yoshida H; Kato S; Tanaka K; Masutani K; Tsukada J; Nomura Y; Mimata H; Kubo M; Yoshimura A
Journal: Immunity
Volume: 19
Issue: 3
Date: 2003 Sep
Year: 2003
Pages: 437-50
Review Status: Peer Reviewed
Abstract:
Suppressor of cytokine signaling-1 (SOCS1/JAB) negatively regulates not only the cytokine-signaling pathway but also lipopolysaccharide (LPS)-induced macrophage activation. We found that SOCS1-deficient dendritic cells (DCs) were also hyperresponsive to interferon-gamma and interleukin-4. To define the role of SOCS1-deficient DCs in vivo, we generated mice in which the SOCS1 expression was restored in T and B cells on a SOCS1(-/-) background. In these mice, DCs were accumulated in the thymus and spleen and produced high levels of BAFF/BLyS and APRIL, resulting in the aberrant expansion of B cells and autoreactive antibody production. SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity.
