References
Query Results -- Details
MGI Accession ID: MGI:2670471
J Number: J:84858
Other Accession IDs:
Title: Integrin requirement for hippocampal synaptic plasticity and spatial memory.
Authors: Chan CS; Weeber EJ; Kurup S; Sweatt JD; Davis RL
Journal: J Neurosci
Volume: 23
Issue: 18
Date: 2003 Aug 6
Year: 2003
Pages: 7107-16
Review Status: Peer Reviewed
Abstract:
The establishment of memory requires coordinated signaling between presynaptic and postsynaptic terminals in the CNS. The integrins make up a large family of cell adhesion receptors that are known to mediate bidirectional signaling between cells or between cells and their external environment. We show here that many different integrins, including alpha3 and alpha5, are expressed broadly in the adult mouse brain and are associated with synapses. Mice with genetically reduced expression of alpha3 integrin fail to maintain long-term potentiation (LTP) generated in hippocampal CA1 neurons. Mice with reduced expression of the alpha3 and alpha5 integrins exhibit a defect in paired-pulse facilitation. Mice with reduced expression of alpha3, alpha5, and alpha8 are defective in hippocampal LTP and spatial memory in the water maze but have normal fear conditioning. These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates.
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