References
Query Results -- Details
MGI Accession ID: MGI:2669572
J Number: J:84755
Other Accession IDs:
Title: A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.
Authors: Rao C; Foernzler D; Loftus SK; Liu S; McPherson JD; Jungers KA; Apte SS; Pavan WJ; Beier DR
Journal: Development
Volume: 130
Issue: 19
Date: 2003 Oct
Year: 2003
Pages: 4665-72
Review Status: Peer Reviewed
Abstract:
Several features of the pigment defect in belted (bt) mutant mice suggest that it occurs as a result of a defect in melanocyte development that is unique from those described for other classical white-spotting mutations. We report here that bt mice carry mutations in Adamts20, a novel member of the ADAMTS family of secreted metalloproteases. Adamts20 shows a highly dynamic pattern of expression in the developing embryo that generally precedes the appearance of melanoblasts in the same region, and is not expressed in the migrating cells themselves. Adamts20 shows remarkable homology with GON-1, an ADAMTS family protease required for distal tip cell migration in C. elegans. Our results suggest that the role of ADAMTS proteases in the regulation of cell migration has been conserved in mammalian development.
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