References
Query Results -- Details
MGI Accession ID: MGI:2664457
J Number: J:83967
Other Accession IDs:
Title: p21Cip1 Nullizygosity increases tumor metastasis in irradiated mice.
Authors: Jackson RJ; Engelman RW; Coppola D; Cantor AB; Wharton W; Pledger WJ
Journal: Cancer Res
Volume: 63
Issue: 12
Date: 2003 Jun 15
Year: 2003
Pages: 3021-5
Review Status: Peer Reviewed
Abstract:
p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate a G1 checkpoint, which allows time for DNA repair before S phase entry. By inhibiting cell cycle progression, p21(Cip1) potentially suppresses tumorigenesis, and in support, we show that p21(Cip1) heterozygous and nullizygous mice develop more tumors than do wild-type mice when exposed to a single dose of gamma-irradiation. Importantly, we also show that p21(Cip1) nullizygosity increases the incidence of metastatic tumors in irradiated mice. We suggest that p21(Cip1) is haploinsufficient for tumor suppression and functions as an antimetastatic agent.
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