References
Query Results -- Details
MGI Accession ID: MGI:2662650
J Number: J:83571
Other Accession IDs:
Title: Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.
Authors: Chen L; Majde JA; Krueger JM
Journal: Brain Res
Volume: 973
Issue: 2
Date: 2003 May 30
Year: 2003
Pages: 214-22
Review Status: Peer Reviewed
Abstract:
Nitric oxide (NO) affects almost every physiological process, including the regulation of sleep. There is strong evidence that NO plays an important role in rapid eye movement sleep (REMS) regulation. To further investigate the role of NO in sleep, we characterized spontaneous sleep in mice with targeted disruptions (knockout; KO) in the neuronal nitric oxide synthase (nNOS) or inducible (i)NOS genes. REMS in nNOS KO mice was substantially lower than that of their control mice. In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period. Results suggest that nNOS and iNOS play opposite roles in REMS regulation.
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