References
Query Results -- Details
MGI Accession ID: MGI:2651750
J Number: J:82192
Other Accession IDs:
Title: Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning.
Authors: Carter AR; Berry EM; Segal RA
Journal: Mol Cell Neurosci
Volume: 22
Issue: 1
Date: 2003 Jan
Year: 2003
Pages: 1-13
Review Status: Peer Reviewed
Abstract:
Neurotrophins were initially identified as critical regulators of neuronal survival. However, these factors have many additional functions. In the developing cerebellum the roles of the neurotrophins BDNF and NT3 include a surprising effect on patterning, as revealed by changes in foliation in neurotrophin-deficient mice. Here we examine the potential role of p75NTR in cerebellar development and patterning. We show that p75NTR is expressed at highest levels in the region of the cerebellum where foliation is altered in BDNF and NT3 mutants. Although the cerebellar phenotype of p75NTR mutant animals is indistinguishable from wild type, mutation of p75NTR in BDNF heterozygotes results in defects in foliation and in Purkinje cell morphologic development. Taken together, these data suggest that p75NTR activity is critical for cerebellar development under pathologic circumstances where neurotrophin levels are reduced.
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