References
Query Results -- Details
MGI Accession ID: MGI:2449309
J Number: J:81429
Other Accession IDs:
Title: X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells.
Authors: Scher I; Ahmed A; Strong DM; Steinberg AD; Paul WE
Journal: J Exp Med
Volume: 141
Issue: 4
Date: 1975 Apr 1
Year: 1975
Pages: 788-803
Review Status: Peer Reviewed
Abstract:
A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus-dependent (T) lymphocytes were normal. The X-linked nature of the immune defect in these mice was therefore attributed to abnormal or absent B lymphocytes. The possible nature of this defect and the similarity of the immune defect in these mice to certain human X-linked immunodeficiency diseases are discussed.
Additional Information:
