References
Query Results -- Details
MGI Accession ID: MGI:2447129
J Number: J:80782
Other Accession IDs:
Title: A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Authors: Borchelt DR; Davis J; Fischer M; Lee MK; Slunt HH; Ratovitsky T; Regard J; Copeland NG; Jenkins NA; Sisodia SS; Price DL
Journal: Genet Anal
Volume: 13
Issue: 6
Date: 1996 Dec
Year: 1996
Pages: 159-63
Review Status: Peer Reviewed
Abstract:
An expression plasmid (MoPrP.Xho), for use in transgenic mice, was developed from the promoter, 5' intronic, and 3' untranslated sequences of the murine prion protein gene. Analyses of mice harboring the MoPrP.Xho construct with cDNA genes encoding the amyloid precursor protein (APP) and human presenilin 1 demonstrated that this vector provides relatively high levels of transgene-encoded polypeptides in brains and hearts of transgenic mice. The MoPrP.Xho vector should be very useful in strategies designed to overexpress a variety of wild-type and disease related mutant transgenes in the heart and brain.
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