References
Query Results -- Details
MGI Accession ID: MGI:2387871
J Number: J:79332
Other Accession IDs:
Title: Matrix metalloproteinase-9 contributes to choroidal neovascularization.
Authors: Lambert V; Munaut C; Jost M; Noel A; Werb Z; Foidart JM; Rakic JM
Journal: Am J Pathol
Volume: 161
Issue: 4
Date: 2002 Oct
Year: 2002
Pages: 1247-53
Review Status: Peer Reviewed
Abstract:
Age-related macular degeneration (AMD) is the primary cause of irreversible photoreceptors loss in adult patients and current therapies are limited. Increased levels of matrix metalloproteinases (MMPs) have been documented in neovascularization of severe ocular pathologies such as AMD and proliferative diabetic retinopathy. We report here that MMP-9 (gelatinase B) expression is induced and temporally regulated in the course of experimental choroidal neovascularization. We used transgenic mice expressing beta-galactosidase reporter gene under the dependence of MMP-9 promoter and RT-PCR analysis on choroidal neovascular structures microdissected from serial sections by laser pressure catapulting to show that MMP-9 expression is up-regulated concomitantly with the appearance of inflammatory cells in the subretinal lesion. In mice deficient in MMP-9 expression the development of choroidal neovascularization induced by laser photocoagulation still occurred, but at a reduced level.
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