References
Query Results -- Details
MGI Accession ID: MGI:56438
J Number: J:7969
Other Accession IDs:
Title: Regional linkage analysis of the dioxin-inducible P-450 gene family on mouse chromosome 9.
Authors: Hildebrand CE; Gonzalez FJ; Kozak CA; Nebert DW
Journal: Biochem Biophys Res Commun
Volume: 130
Issue: 1
Date: 1985 Jul 16
Year: 1985
Pages: 396-406
Review Status: Peer Reviewed
Abstract:
The dioxin-inducible P-450 gene family in the C57BL/6N mouse comprises two genes, P1-450 and P3-450. Restriction endonuclease-digested genomic DNA was probed with P1-450 and P3-450 full-length cDNA clones in an attempt to find species-specific fragment length differences between mouse and hamster cell lines and any restriction fragment length polymorphism among four inbred mouse strains. With this Southern blot hybridization technique, PstI fragments were used to distinguish between the mouse and hamster P1-450/P3-450 genes, and PvuII fragments were used to distinguish P3-450 differences between the AKR/J and C57L/J inbred strains. Analysis of nineteen mouse X hamster somatic cell hybrid lines and sixteen AKXL (AKR/J X C57L/J) recombinant inbred lines showed that the P1-450/P3-450 genes are located near the Mpi-1 locus, between the Thy-1 and Pk-3 loci, in the middle portion of mouse chromosome 9.
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