References
Query Results -- Details
MGI Accession ID: MGI:2385527
J Number: J:78607
Other Accession IDs:
Title: Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity.
Authors: Ntambi JM; Miyazaki M; Stoehr JP; Lan H; Kendziorski CM; Yandell BS; Song Y; Cohen P; Friedman JM; Attie AD
Journal: Proc Natl Acad Sci U S A
Volume: 99
Issue: 17
Date: 2002 Aug 20
Year: 2002
Pages: 11482-6
Review Status: Peer Reviewed
Abstract:
Stearoyl-CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane phospholipids, triglycerides, wax esters, and cholesterol esters. Several SCD isoforms (SCD1-3) exist in the mouse. Here we show that mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain. The protection from obesity involves increased energy expenditure and increased oxygen consumption. Compared with the wild-type mice the SCD1-/- mice have increased levels of plasma ketone bodies but reduced levels of plasma insulin and leptin. In the SCD1-/- mice, the expression of several genes of lipid oxidation are up-regulated, whereas lipid synthesis genes are down-regulated. These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.
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