References
Query Results -- Details
MGI Accession ID: MGI:2384672
J Number: J:78492
Other Accession IDs:
Title: Mouse models for generating P53 gene mutation spectra.
Authors: Zielinski B; Liu Z; Hollstein M; Hergenhahn M; Luo J
Journal: Toxicol Lett
Volume: 134
Issue: 1-3
Date: 2002 Aug 5
Year: 2002
Pages: 31-7
Review Status: Peer Reviewed
Abstract:
The p53 tumor suppressor gene lends itself to mutation spectra analysis, because the frequency of point mutations in human tumors is high, the locations of inactivating tumor mutations are numerous and dispersed, and all possible base substitutions are observed in human cancer. P53 tumor mutations induced experimentally in mice exposed to carcinogens have been described, but have not yet contributed significantly to our understanding of mutagenic mechanisms or of the origins of mutations in human cancers. Recently, gene-targeting technology has allowed development of a new mouse model, which explores experimentally the endogenous and environmental factors that may contribute to neoplastic disease in humans.
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