References
Query Results -- Details
MGI Accession ID: MGI:56279
J Number: J:7810
Other Accession IDs:
Title: Mast-cell precursors in the skin of mouse embryos and their deficiency in embryos of Sl/Sld genotype.
Authors: Hayashi C; Sonoda T; Nakano T; Nakayama H; Kitamura Y
Journal: Dev Biol
Volume: 109
Issue: 1
Date: 1985 May
Year: 1985
Pages: 234-41
Review Status: Peer Reviewed
Abstract:
Concentration of mast-cell precursors in the skin and liver of mouse embryos was evaluated by the limiting dilution analysis. The concentration of mast-cell precursors in the liver of (WB X C57BL/6)F1 (hereafter WBB6F1)-+/+ embryos reached the maximum level at Day 15 of the pregnancy, whereas the concentration in the skin at Day 17. The concentration of 17-day skin was about 10 times as high as that of 15-day liver. Appearance of morphologically identifiable mast cells in the skin followed the increase in concentration of the skin precursors. Concentrations of mast-cell precursors in the skin and liver of mutant embryos of Sl/Sld genotype were also measured to clarify the mechanism of mast-cell depletion in this mutant. Although the concentration of mast-cell precursors in the liver of WBB6F1-Sl/Sld embryos was comparable to that of the WBB6F1-+/+ embryos, the concentration in the skin of the Sl/Sld embryos was about 1% that of the +/+ embryos. Moreover, the concentration of morphologically identifiable mast cells in the skin of the Sl/Sld embryos was about 0.1% that of the +/+ embryos. Thus, mast-cell production in Sl/Sld embryos seemed to be suppressed at two stages; (1) during deficient invasion of liver-derived precursors into the skin, or the decreased proliferation of these cells, or both of these causes, (2) during differentiation of the precursors into mast cells.
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