References
Query Results -- Details
MGI Accession ID: MGI:2180292
J Number: J:76800
Other Accession IDs:
Title: Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo.
Authors: North TE; de Bruijn MF; Stacy T; Talebian L; Lind E; Robin C; Binder M; Dzierzak E; Speck NA
Journal: Immunity
Volume: 16
Issue: 5
Date: 2002 May
Year: 2002
Pages: 661-72
Review Status: Peer Reviewed
Abstract:
Hematopoietic stem cells (HSCs) are first found in the aorta-gonad-mesonephros region and vitelline and umbilical arteries of the midgestation mouse embryo. Runx1 (AML1), the DNA binding subunit of a core binding factor, is required for the emergence and/or subsequent function of HSCs. We show that all HSCs in the embryo express Runx1. Furthermore, HSCs in Runx1(+/-) embryos are heterogeneous and include CD45(+) cells, endothelial cells, and mesenchymal cells. Comparison with wild-type embryos showed that the distribution of HSCs among these various cell populations is sensitive to Runx1 dosage. These data provide the first morphological description of embryonic HSCs and contribute new insight into their cellular origin.
Additional Information:
