References
Query Results -- Details
MGI Accession ID: MGI:2177089
J Number: J:75581
Other Accession IDs:
Title: The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes.
Authors: Croker BA; Tarlinton DM; Cluse LA; Tuxen AJ; Light A; Yang FC; Williams DA; Roberts AW
Journal: J Immunol
Volume: 168
Issue: 7
Date: 2002 Apr 1
Year: 2002
Pages: 3376-86
Review Status: Peer Reviewed
Abstract:
We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in B lymphocyte development and function through examination of rac2(-/-) mice. Rac2-deficient mice displayed peripheral blood B lymphocytosis and marked reductions in peritoneal cavity B-1a lymphocytes, marginal zone B lymphocytes, and IgM-secreting plasma cells as well as reduced concentrations of serum IgM and IgA. The rac2(-/-) B lymphocytes exhibited reduced calcium flux following coligation of B cell AgR and CD19 and reduced chemotaxis in chemokine gradients. T cell-independent responses to DNP-dextran were of reduced magnitude, but normal kinetics, in rac2(-/-) mice, while T-dependent responses to nitrophenyl-keyhole limpet hemocyanin were subtly abnormal. Rac2 is therefore an essential element in regulating B lymphocyte functions and maintaining B lymphocyte populations in vivo.
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