References
Query Results -- Details
MGI Accession ID: MGI:2177077
J Number: J:75569
Other Accession IDs:
Title: Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis.
Authors: Pani L; Horal M; Loeken MR
Journal: Genes Dev
Volume: 16
Issue: 6
Date: 2002 Mar 15
Year: 2002
Pages: 676-80
Review Status: Peer Reviewed
Abstract:
Pax-3 is a transcription factor that is expressed in the neural tube, neural crest, and dermomyotome. We previously showed that apoptosis is associated with neural tube defects (NTDs) in Pax-3-deficient Splotch (Sp/Sp) embryos. Here we show that p53 deficiency, caused by germ-line mutation or by pifithrin-alpha, an inhibitor of p53-dependent apoptosis, rescues not only apoptosis, but also NTDs, in Sp/Sp embryos. Pax-3 deficiency had no effect on p53 mRNA, but increased p53 protein levels. These results suggest that Pax-3 regulates neural tube closure by inhibiting p53-dependent apoptosis, rather than by inducing neural tube-specific gene expression.
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