References
Query Results -- Details
MGI Accession ID: MGI:2176132
J Number: J:75249
Other Accession IDs:
Title: Haptoglobin, inflammation, and tumorigenesis in the MIN mouse.
Authors: Barbour K W; Davis T; White A; Baumann H; Berger F G
Journal: Redox Rep
Volume: 6
Issue: 6
Date: 2001
Year: 2001
Pages: 366-8
Review Status: Peer Reviewed
Abstract:
We have determined that the MIN mouse, which is predisposed to adenomas of the small and large intestine, exhibits chronic inflammation characterized by the induction of haptoglobin (HP), as well as other acute phase proteins. Inflammation is initiated at about 40-70 days of age, and is maintained throughout the life of the animal. Delayed onset of inflammation brought on by dietary means is associated with a reduction in tumor number and longer life-span. Knockout mice that lack haptoglobin exhibit an increase in tumor number, indicating that the acute phase reactant suppresses tumorigenesis, perhaps through inhibition of the inflammatory response. The MIN mouse is, therefore, a useful model for studying the roles of HP and inflammation in tumorigenesis in vivo.
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