References
Query Results -- Details
MGI Accession ID: MGI:2159059
J Number: J:74752
Other Accession IDs:
Title: Reduction of marginal zone B cells in CD22-deficient mice.
Authors: Samardzic T; Marinkovic D; Danzer CP; Gerlach J; Nitschke L; Wirth T
Journal: Eur J Immunol
Volume: 32
Issue: 2
Date: 2002 Feb
Year: 2002
Pages: 561-7
Review Status: Peer Reviewed
Abstract:
CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition.
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