References
Query Results -- Details
MGI Accession ID: MGI:2157226
J Number: J:73948
Other Accession IDs:
Title: Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice.
Authors: Cretney E; Takeda K; Yagita H; Glaccum M; Peschon JJ; Smyth MJ
Journal: J Immunol
Volume: 168
Issue: 3
Date: 2002 Feb 1
Year: 2002
Pages: 1356-61
Review Status: Peer Reviewed
Abstract:
We have previously implicated TNF-related apoptosis-inducing ligand (TRAIL) in innate immune surveillance against tumor development. In this study, we describe the use of TRAIL gene-targeted mice to demonstrate the key role of TRAIL in suppressing tumor initiation and metastasis. Liver and spleen mononuclear cells from TRAIL gene-targeted mice were devoid of TRAIL expression and TRAIL-mediated cytotoxicity. TRAIL gene-targeted mice were more susceptible to experimental and spontaneous tumor metastasis, and the immunotherapeutic value of alpha-galactosylceramide was diminished in TRAIL gene-targeted mice. TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells.
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