References
Query Results -- Details
MGI Accession ID: MGI:55913
J Number: J:7443
Other Accession IDs:
Title: Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus.
Authors: Lyon MF
Journal: Cell
Volume: 37
Issue: 2
Date: 1984 Jun
Year: 1984
Pages: 621-8
Review Status: Peer Reviewed
Abstract:
Transmission ratios of male mice heterozygous for various combinations of partial t-haplotypes provide evidence in support of a model for the genetic basis of ratio distortion, involving two or more distorter genes acting on a responder locus. The t form of the responder locus, Tcr, in the medial part of the haplotype, must be present and heterozygous for distortion to occur. When the responder alone is present, as in t low haplotypes, the chromosome carrying it is transmitted in a low ratio (less than 50%). The t forms of the distorter loci act additively, in cis or trans, to raise the transmission of whichever chromosome carries Tcr. Identified distorter loci are Tcd-1, in the proximal part of the haplotype, Tcd-2, distal to Tcr, and probably Tcd-3, lying between Tcr and Tcd-2. In the absence of Tcr the distorters are transmitted normally. The system is compared with the SD system of Drosophila.
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