References
Query Results -- Details
MGI Accession ID: MGI:2153408
J Number: J:72695
Other Accession IDs:
Title: TNFalpha promotes proliferation of oligodendrocyte progenitors and remyelination.
Authors: Arnett HA; Mason J; Marino M; Suzuki K; Matsushima GK; Ting JP
Journal: Nat Neurosci
Volume: 4
Issue: 11
Date: 2001 Nov
Year: 2001
Pages: 1116-22
Review Status: Peer Reviewed
Abstract:
Here we used mice lacking tumor necrosis factor-alpha (TNFalpha) and its associated receptors to study a model of demyelination and remyelination in which these events could be carefully controlled using a toxin, cuprizone. Unexpectedly, the lack of TNFalpha led to a significant delay in remyelination as assessed by histology, immunohistochemistry for myelin proteins and electron microscopy coupled with morphometric analysis. Failure of repair correlated with a reduction in the pool of proliferating oligodendrocyte progenitors (bromodeoxyuridine-labeled NG2+ cells) followed by a reduction in the number of mature oligodendrocytes. Analysis of mice lacking TNF receptor 1 (TNFR1) or TNFR2 indicated that TNFR2, not TNFR1, is critical to oligodendrocyte regeneration. This unexpected reparative role for TNFalpha in the CNS is important for understanding oligodendrocyte regeneration/proliferation, nerve remyelination and the design of new therapeutics for demyelinating diseases.
Additional Information:
