References
Query Results -- Details
MGI Accession ID: MGI:55779
J Number: J:7308
Other Accession IDs:
Title: Monocytosis in the BXSB model for systemic lupus erythematosus.
Authors: Wofsy D; Kerger CE; Seaman WE
Journal: J Exp Med
Volume: 159
Issue: 2
Date: 1984 Feb 1
Year: 1984
Pages: 629-34
Review Status: Peer Reviewed
Abstract:
Autoimmunity in BXSB mice is associated with a progressive increase in the number of peripheral blood mononuclear cells (PBMC). This is due to a marked rise in circulating monocytes, identified by: (a) their appearance on light and electron microscopy; (b) their surface antigenic characteristics; (c) their expression of Fc receptors; and (d) their capacity for phagocytosis. Among murine models for systemic lupus erythematosus, only the BXSB strain is characterized by monocytosis, suggesting that cells of monocytic lineage may contribute significantly to the pathogenesis of autoimmune disease in BXSB mice.
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