References
Query Results -- Details
MGI Accession ID: MGI:2150232
J Number: J:71491
Other Accession IDs:
Title: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
Authors: Cho H; Mu J; Kim JK; Thorvaldsen JL; Chu Q; Crenshaw EB rd; Kaestner KH; Bartolomei MS; Shulman GI; Birnbaum MJ
Journal: Science
Volume: 292
Issue: 5522
Date: 2001 Jun 1
Year: 2001
Pages: 1728-31
Review Status: Peer Reviewed
Abstract:
Glucose homeostasis depends on insulin responsiveness in target tissues, most importantly, muscle and liver. The critical initial steps in insulin action include phosphorylation of scaffolding proteins and activation of phosphatidylinositol 3-kinase. These early events lead to activation of the serine-threonine protein kinase Akt, also known as protein kinase B. We show that mice deficient in Akt2 are impaired in the ability of insulin to lower blood glucose because of defects in the action of the hormone on liver and skeletal muscle. These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis.
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