References
Query Results -- Details
MGI Accession ID: MGI:2150206
J Number: J:71465
Other Accession IDs:
Title: Quantitative trait loci for body weight in the intercross between SM/J and A/J mice.
Authors: Anunciado RV; Nishimura M; Mori M; Ishikawa A; Tanaka S; Horio F; Ohno T; Namikawa T
Journal: Exp Anim
Volume: 50
Issue: 4
Date: 2001 Jul
Year: 2001
Pages: 319-24
Review Status: Peer Reviewed
Abstract:
We performed a genome-wide quantitative trait locus (QTL) analysis of body weight at 10 weeks of age in a population of 321 intercross offspring from SM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. Interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) and Bwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight.
Additional Information:
